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When you eat, GLP-1 is released, prompting the pancreas to produce insulin

A systematic review of the antidepressant effects of glucagon-like peptide 1 (GLP-1) functional agonists: further link between metabolism and psychopathology: special section on translational and neuroscience studies in affective disorders

95% confidence interval, 0.72 to 0.90

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10-13 In subsequent trials where higher doses of the GLP-1/GIP agonists were used in non-diabetic obese subjects, weight loss of 15% to 21% of body weight was seen