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Acknowledgments We wish to thank the Spanish network of Emerging crops for the diversification of agronomic and food systems through the use of crops with high nutritional value, project RED2022-134382-T funded by the Spanish Ministry of Science, Innovation and Universities and Carlos Garca and his team from the company Innovaciones Agroalimentarias S.L., Valladolid, Spain, for critical comments and stimulating discussions of the manuscript

Para assegurar a segurana dos alimentos, diversas normas e padres internacionais, como as estabelecidas pelo Codex Alimentarius e regulamentaes locais, como as da Agncia Nacional de Segurana Alimentar (ANVISA) no Brasil, so seguidos

Side effects still happen, especially at higher doses or in the first weeks of use

Defined TB-500 lacks identified human exposure data

These reactions are distinct from the "feeling sick" associated with digestion and require medical attention