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Skin texture and calmness often shift first, while firmness and hair fullness follow over a longer stretch of steady use

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The animals were treated daily during five weeks with L-NAME (10 mg/kg b.w.), L-arginine (100 mg/kg b.w.), NaBPC157 (10 g/kg b.w.) and their combinations (L-NAME + NaBPC157, L-NAME + L-arginine) intraperitoneally