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This is an important caveat that any responsible clinical discussion must acknowledge

High homocysteine levels contribute to neurodegenerative disorders, psychiatric disorders, and cardiovascular disease [12]

combined use is speculative and may compound adverse metabolic and gastrointestinal effects with no safety framework to guide dosing

Is Vitamin B12 injection better than taking a B12 supplement

Simultaneously, the preservation of SAM levels maintains cellular capacity for critical methylation reactions including histone modifications, DNA methylation, and protein methylation that regulate gene expression and protein function

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