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The incidence typically decreases over time as the body adapts to the medication, with many patients reporting improvement after several weeks at a stable dose

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A similar situation was observed in rbohD mutants of Arabidopsis, also exhibiting decreased apoplastic localization (Otulak-Kozie et al., 2023)

doi: 10.1080/21655979.2021.2000195 193

Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice