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Definition of therapy courses Medication orders were aggregated into discrete courses of therapy. For a given patient and drug, multiple orders were considered part of the same course if the gap between the end of one order and the start of the next was 30 days

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Here, we systematize the therapeutic strategies into three main periods precisely: (i) period of preventing biofilm formation: interfering the colony effect, mass transport, chemical bonds and signaling pathway of plankton in the initial adhesion stage