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Blocking metallothionein-2 expression by copper-doped carbon dots induces cellular antioxidant system collapse for antitumor therapy

Lancet 381(9863):295302 Bruix J et al (2017) Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

However, extrapolation to human disease requires caution due to differences in immune responses, disease progression, and selenium metabolism between mice and humans

Anisomycin could also increase the contents of LPO, MDA, and Fe 2+ in HuOCSCs, while decreasing the content of T-GSH