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These effects are likely tied to glucagon receptor signaling, which drives fat oxidation and reduces lipid synthesis in hepatic tissue

Barrier material like a washcloth or small towel to prevent direct contact between ice packs and medication

Fat intake is the second underappreciated variable

Hypoglycaemia (low blood sugar) is another consideration, particularly for people with epilepsy who also have diabetes and take insulin or sulphonylureas

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