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(Wei et al., 2016) confirmed Erdogdus report that exenatide stimulation of human umbilical vein endothelial cells (HUVECs) led to the phosphorylation of eNOS, inducing NO production, an effect that could be eliminated by GLP-1RAs inhibitors and by specific inhibitors of signaling pathways
Sperm-specific piRNA expression decreases by 45%, leading to retrotransposon activation and increased genomic instability (98)
They meet the drug definition and injectables cannot be natural health products
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Additionally, conducting preclinical and clinical studies is crucial to evaluate safety, pharmacokinetics, and therapeutic outcomes in diverse patient populations