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In their later study, Vaillancourt and his colleagues demonstrated that 4-HNE was cytotoxic and could induce apoptosis in human osteoarthritic chondrocytes [84]

232 Overall, data gaps persist regarding long-term safety, optimal dosing, herbdrug interactions, and age-specific pharmacokinetics in these vulnerable groups

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SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival of the Article. Clinical Cancer Research 19(3): 560570

describe how these mechanisms are increasingly linked to the metabolic-inflammatory axis of OA, offering future therapeutic targets beyond conventional anti-inflammatories (Wu et al., 2025)