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Clinical Considerations Disease-associated maternal and/or embryofetal risk Appropriate weight gain based on pre-pregnancy weight is currently recommended for all pregnant patients, including those who already have overweight or obesity, because of the obligatory weight gain that occurs in maternal tissues during pregnancy

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Clinical course The clinical course of APAP hepatotoxicity in patients with a single overdose can be classically divided into 4 sequential stages (table below ), however, it should be noted that the course is variable and may not follow the four-stage sequential pattern seen after a single oral ingestion

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