However, overexpression of Keap1 was shown to repress the nuclear accumulation and transcriptional activity of Nrf2, while the addition of phase II inducers, which could upregulate Nrf2, was able to relieve this repression
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In the adjuvant arthritis studies, the lesions' development was considerably reduced after a single NaBPC157 application and even more attenuated in rats treated daily with NaBPC157
