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Extreme responses to a combination of DNA-damaging therapy and immunotherapy in CDK12-altered metastatic castration-resistant prostate cancer: A potential therapeutic vulnerability

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Severe multisystem symptoms require specialist evaluation Seizures, metabolic strokes, severe weakness, cardiomyopathy, developmental regression, exercise-induced rhabdomyolysis, lactic acidosis, major hearing or vision loss and strong maternal inheritance patterns may require neurological, metabolic or genetic evaluation

Most patients tolerate peptide therapy very well

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