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Semaglutide was associated with a significant reduction on weight loss related outcomes, including the absolute value of weight loss (WMD -897, 95% CI -1073 to -721), percentage of weight loss (WMD -1000, 95% CI -1199 to -800), body mass index (WMD -319, 95% CI -402 to -237) and waist circumference (WMD -721,95% CI -887 to -556)
For all-cause mortality, the survival probabilities were 86.3% with GLP-1RA use and 88.9% with SGLT2 inhibitors at five years
Renovation of old drugs can peptide drug conjugates lead the post-ADC era
Fig.1 Structure of AOD-9604 With obesity and metabolic disorders on the rise, peptides like AOD-9604 are attracting attention for their potential role in weight loss and fat metabolism
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