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Mitochondrial insufficiency in astrocytes is a hallmark of PD, leading to a profound deterioration of astrocytic homoeostatic, supportive, and protective capabilities

In the original 2017 mouse study, FOXO4-DRI was reported as well-tolerated in vivo at the dosing used

Injection frequency is adjusted based on symptoms, labs, and lifestyle needs

Curie A, Touil N, Gaillard S, Galanaud D, Leboucq N, Deschenes G, Morin D, Abad F, Luaute J, Bodenan E, Roche L, Acquaviva C, Vianey-Saban C, Cochat P, Cotton F, Bertholet-Thomas A (2020) Neuropsychological and neuroanatomical phenotype in 17 patients with cystinosis

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