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NLRs-Inflammasome Pathway: DAMP-mediated NLRP3 Inflammasome Activation, Pyroptosis, and IL-1 Release Activated NLRs manifest diverse functionalities, which can be comprehensively classified into four primary functions: inflammasome formation, signal transduction, transcriptional activation, and autophagy

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Experimental work has focused on receptor pharmacology, cyclic AMP linked signaling, food intake and energy expenditure pathways, hepatic lipid handling, inflammatory markers, and cross-tissue metabolic communication in animal and biochemical models