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As it is a syndrome clustering different features, the common causative aetiology is yet unknown

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McGuire DK, Busui RP, Deanfield J, Inzucchi SE, Mann JFE, Marx N et al (2023) Effects of oral semaglutide on cardiovascular outcomes in individuals with type 2 diabetes and established atherosclerotic cardiovascular disease and/or chronic kidney disease: design and baseline characteristics of SOUL, a randomized trial