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In: Bekker A, Chen, (D)D-G, Ferreira JT, editors

Tirzepatide goes a step further it activates two hormones: GIP + GLP-1, which leads to a stronger insulin response and greater appetite suppression

The health plans board of trustees eliminated coverage of this class of medications for weight loss starting in April

doi: 10.1023/A:1010635131228 46 SalehiMGastaldellliADAlessioDA

More serious but less common adverse effects include acute pancreatitis, gallbladder disease, dehydration leading to acute kidney injury, and potential worsening of diabetic retinopathy with rapid HbA1c reduction (particularly with semaglutide)

Popoff, V., Adolf, F., Brugger, B