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These fluctuations can influence everything from water retention to insulin sensitivity

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The chronic activation of stromal cells and invading immune cells depletes the tissue of glucose and acidifies the environment with lactate

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The inhibitor DON has been shown to irreversibly inhibit GLS activity

and accordingly nerve damage appeared in various brain areas, with most prominent damage in corpus callosum, laterodorsal thalamus, nucleus reunions, anterior horn motor neurons, regional heterogeneities which suggest differences in the underlying pathophysiology as it had been previously claimed (72)