ADT-induced changes in metabolites related to carnitine synthesis and mitochondrial fatty acid oxidation may help explain our previous observation of mitochondrial dysfunction in fatigued patients (Figure 1E), including cysteinylglycine and oxidized cys-gly (Figure 3B)
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The mechanisms may involve changes in testosterone levels, blood flow, and energy balance
However, this does not inevitably lead to a loss of the biological function of these -defensins [147]
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