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To confirm whether an increase in UCK2 activity as a result of pyrimidine stress was the driving force behind mitochondrial biogenesis signalling, we knocked down UCK2 in cells using siRNA (Fig

As a form of autophagy, specifically macroautophagy, lipophagy mediates the hydrolysis of TG stored in lipid droplets via fusion of the engulfed droplets with lysosomes

Data availability Proteomic results and summary association data are available through a dashboard at Individual participant data from the STEP 1 and STEP 2 clinical trials can be shared in datasets in a de-identified and anonymized format

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