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Some are presented below to exemplify different multitargeting approaches

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229,230 The leading response of astrocytes to infectious agents is reactive astrogliosis, which erects parenchymal barriers and encapsulates brain abscesses, thus preventing infection spread

Copper is also bound by regulatory proteins including metallothioneins, copper chaperones (ATOX1, COX17, CCS), and the major plasma copper-binding protein ceruloplasmin

Acknowledgments: We thank our study participants without whom this work would not be possible and the expert research kitchen, metabolic ward and indirect calorimetry teams at the Translational Research Institute and Pennington Biomedical Research Center for the excellent execution of this trial

Pharmacol Ther (2020) 213:107584