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Renal issues are now being treated with an increasing array of nano-based medication delivery technologies (Merlin and Li 2022)

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Diabetes Investig

Conversely, PGC-1 inhibits liver cancer cell metastasis by suppressing aerobic glycolysis through the downstream target PDK1 in the WNT/-catenin pathway 42

One retrospective study of intra-articular knee injections reported symptomatic improvement lasting over six months following a single injection in 7 of 12 patients, suggesting potential for sustained effects beyond active treatment periods

(4) Single route of administration: the current preclinical animal studies and clinical human trials predominantly employ oral administration as the primary intervention method for BBR, with a notable lack of research on alternative delivery approaches such as transdermal absorption