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2015 May;100(5):2135-6

And rather than trading muscle preservation for less overall weight loss, the triplet group actually lost more total weight: 30 pounds versus 23 pounds for semaglutide alone

GI adverse events: prevalence, mechanism, and management The most common side effects of GLP-1 RAs and their multi-agonist derivatives are GI adverse events

If you experience: Severe abdominal pain Persistent vomiting Fever Rapid heart rate You should contact your healthcare provider immediately

Primary care providers may also feel more comfortable prescribing GLP-1 therapies once affordability improves

While changes in appetite and hunger may occur, treatment decisions should be based primarily on objective clinical outcomes rather than subjective hunger sensations