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The mechanism likely involves GLP-1 receptors in the brain

Semaglutide is typically initiated at a low dose and is gradually increased over time

Efficacy in Weight Loss: Semaglutide: Clinical trials have shown that semaglutide can lead to significant weight loss, with users typically experiencing around 15-20% reduction in body weight over a period of 68 weeks

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These dangers are amplified in certain high-risk populations, including those with a history of diabetic ketoacidosis, poor diabetes control, chronic kidney disease, and liver disease