The serine/glycine synthesis pathway branches from glycolysis via the glycolytic intermediate 3-phospho-glycerate, which can be converted into serine via three enzymatic reactions catalyzed by PHGDH, PSAT1, and PSPH, followed by the reversible interconversion of serine into glycine by SHMT1/2 (Figure 1)(2)
This was a small pilot study (6 participants) results are preliminary and require confirmation in larger trials
Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects
During pregnancy and breastfeeding, the demand for B vitamins, particularly folate (vitamin B9), escalates due to its role in reducing the risk of birth defects and supporting foetal growth
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Thus, trigonelline might be an interesting therapeutic strategy as an NAD + modulator to explore in sarcopenia and possibly other chronic conditions