Some patients find that even one drink triggers a level of nausea that keeps them in bed the next morning
10.1016/j.nbd.2013.01.006 18
Single-cell RNA sequencing study identified that AGE-induced epigenetic modifications in retinal endothelial cells enhance the expression of VEGF and interleukin-6 (IL-6), contributing to BRB breakdown (73)
One meta-analysis (April 2025) found no difference in incidence of aspiration (OR 1.04, 95% CI 0.871.25) despite the patients taking GLP-1 RAs having a higher incidence of residual gastric contents
There are also narratives around skinny shots claiming to boost metabolism, aid fat breakdown, or provide energy support, but there is limited scientific data supporting these assertions
Common side effects include gastrointestinal symptoms (nausea, vomiting, diarrhoea), allergic reactions (rash, bronchospasm in people with asthma), anaphylactoid reactions with intravenous use, and headache particularly when used with nitrates