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BPC-157 (Body Protection Compound-157) is a synthetic, stable pentadecapeptide of 15 amino acids derived from a partial sequence of a protein identified in gastric juice

In response, the brain activates the microglia which undergo morphological changes, that is, polarization to the M2 phenotype, and begin producing various inflammatory mediators, including TNF- , IL-1, and IL-6

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The apoptosis involved in SIMI encompasses the activation or inhibition of multiple pathways, including TNF- and MAPK-related, PI3K/AKT/mTOR, and NF-B signaling pathways, with the release of various inflammatory factors that directly lead to myocardial damage, resulting in increased secretion of inducible NO synthase and excessive production of NO (98,104)