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These modifications enable investigation of prolonged GLP-1 receptor interactions in model systems, which would not be possible with native GLP-1 due to its rapid degradation in the body

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Animal studies have documented potential developmental effects at high doses, which led the FDA to assign a Category C classificationa label indicating caution rather than proven danger in humans

A strong example of how evidence comes together across study designs to inform care: To view or add a comment, sign in Exciting to see an insightful new Lilly study using Truveta Data, where they greater weight loss with tirzepatide compared to semaglutide among adults with obesity in routine clinical care

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