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When prescribed and monitored by a medical provider, side effects are generally mild and may include temporary redness at the injection site, flushing, or lightheadedness

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Hyperinsulinemia and ectopic lipid accumulation promote activation of pro-inflammatory pathways, including Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-B) signaling and NLRP3 inflammasome activation, which in turn exacerbate loss of immune tolerance [52,53]