Administration of exogenous GLP-1 (but not GIP) leads to a significant increase in endogenous insulin secretion
When we applied the same methods used in the GLP-1 analysis, these drugs showed no difference in fracture risk between the exposure and non-exposed patients
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Existing preclinical and clinical evidence links GLP-1 receptor agonist use with differing effects across major eye diseases, showing a generally consistent association with reduced glaucoma incidence, mixed and nuanced findings in diabetic retinopathy, and divergent signals in age-related macular degeneration (AMD) depending on disease subtype