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Chemical modification of RNA plays a crucial role in regulating gene expression programs in a temporal and spatial manner during development

The patients who respond to thiamin treatment (from a few mg/day to doses above 1,000 mg/day) exhibit PDHC deficiency due to the decreased affinity of PDHC for TPP (108, 109)

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Thus, along with the mitochondria, the ER is an important source of ROS production

Unless otherwise specified, the term 'lactate' throughout the present review refers to L-lactate, the predominant enantiomer produced by mammalian lactate dehydrogenase (LDH)

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