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Regarding the drug metabolism, S-methyltransferase catalyzes S-methylation of aromatic heterocyclic sulfhydryl compounds including anticancer and immunosuppressive thiopurines such as 6-mercaptopurine, 6-thioguanine and azathioprine (Fig

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doi: 10.2147/NDS.S74718

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The findings are compelling as proof of concept, and they are mechanistically coherent with what the human observational and clinical data suggest