glp-1 drugs moa Frontiers The GLP-1 Agonists and Obesity:

Bone (2003) 33(1):809.10.1016/S8756-3282(03)00165-0 226 OchiaiHOkadaSSaitoAHoshiKYamashitaHTakatoTet alInhibition of insulin-like growth factor-1 (IGF-1) expression by prolonged transforming growth factor-beta1 (TGF-beta1) administration suppresses osteoblast differentiation

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Metabolic reprogramming in osteoclasts

doi: 10.3390/pharmaceutics15071920 111 ZakariaNKhalilSRAwadAKhairyGM

Although GLP-1RAs are well established for treating obesity, type 2 diabetes, and for reducing cardiovascular risk, their potential role in inflammatory diseases such as RA has not been clearly defined

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