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2019 Oct 3;11(10):2362

Traina G

In post hoc analyses of the randomised clinical controlled LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) trial, patients assigned to GLP-1RAs (liraglutide) had a reduced risk of prostate cancer (HR 0.54, 95% CI 0.34, 0.88) compared with patients assigned to placebo in addition to standard care

By contrast, inhibition of Sirt1 using sirtinol had the opposite effect

The important metric is tissue residence time

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