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To measure the integrity of the model, the paracellular marker sodium fluorescein (SF

The cardiovascular safety demonstrated by tirzepatide in this analysis and SURPASS-4 paved the way for a large-scale cardiovascular outcomes trial

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Via high-butyrate diet intervention and adoptive transfer experiments, it confirmed that a high-butyrate diet can induce the differentiation of follicular Tregs through HDAC inhibition, suppress the production of type II collagen (CII)-specific autoantibodies, and reduce joint swelling and bone erosion