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consulted for Eli Lilly & Co., and D.H.vR

Three main drivers of menstrual dysfunction in PCOS (Wojda, et al., 2025)

Metabolism 47 , 993997 (1998)

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, distinguishing it from traditional GLP-1 therapies

Once reconstituted, the liquid solution is highly sensitive to thermal degradation and must be continuously refrigerated at 4C

The H-bond network is only observed for OCTN2 in the occluded conformation and is absent in the inward-facing conformation, supporting that the network helps to stabilise a kinked conformation of TM11 that packs against TM2