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"Lilly's phase 2 retatrutide results published in The New England Journal of Medicine show the investigational molecule achieved up to 17.5% mean weight reduction at 24 weeks in adults with obesity and overweight"
It has approximately 5-fold greater affinity for GIPR than GLP-1R
The FDA permits licensed providers to prescribe GLP-1 medications remotely when a genuine doctor-patient relationship exists
Unlike existing GLP-1 therapies, which are peptide-based and require injections, orforglipron is a synthetic, non-peptide small molecule: orally bioavailable, once-daily, and independent of food or water intake
Patients who started GLP-1s shortly after diagnosis had higher metformin use and fewer fertility procedures
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