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Some patients split doses during titration to manage side effects, but this requires a modified dosing schedule

SGLT2 inhibitors when used as an add-on therapy to metformin, insulin, thiazolidinediones, DPP-4 inhibitors, GLP-1 RAs, sulfonylureas, or metformin DPP-4 inhibitor were similarly effective in reducing A1c levels as when used in monotherapy (22,139)

As is generally true for the complex biochemistry of our bodies, too much of any one thing can turn detrimental

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