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(2016) 310:E50514

Self-delivery nanomedicine to overcome drug resistance for synergistic chemotherapy

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Drug discovery is a tough and risky business with roughly only one in five thousand compounds tested by researchers ever reaching clinical application

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Given that species which have GS-like genes from the first expansion (Clade 2) have retained the progenitor housekeeping gene (Clade 1), and those that have GS-like genes from the second expansion (Clade 3) have retained both Clade 1 and 2, this suggests that the role of each expansion does not supersede its predecessor(s)