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This is due to a phenomenon termed plasma skimming, in which erythrocytes that are primarily in the center of vessels continue to flow in the interlobular artery towards the superficial cortex, while the plasma in the periphery of the capillary is captured by the juxtamedullary afferent arterioles and ultimately flows into vasa recta

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However, this combination requires careful medical oversight to optimize dosing and minimize the risk of side effects, especially hypoglycemia (low blood sugar), which can be more likely when these medications are used together

It sent parents around the world into a panic