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The mechanism involves altered calcium channel activity, particularly affecting voltage-gated calcium channels (CaVs) and store-operated calcium entry pathways, leading to either excessive calcium influx or impaired calcium release from intracellular stores, ultimately resulting in cellular dysfunction and reduced fertilization potential (39)
Although the included studies were conducted in rodent models, Met has long been (1950s) used clinically for diabetes and shows benefits in improving testosterone levels and sperm parameters in men []
However, any mucosal site may be affected
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