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Glutathione deficiency increases susceptibility to oxidative stress, which may be the underlying cause of many diseases including cancer, heart disease, Parkinsons, and Alzheimers [8]

Yusta B, Matthews D, Flock GB, Ussher JR, Lavoie B, Mawe GM, Drucker DJ (2017) Glucagon-like peptide-2 promotes gallbladder refilling via a TGR5-independent, GLP-2R-dependent pathway

44% reduction)

Rat liver glutathione peroxidase: Purification and study of multiple forms

Adding a second injectable during this titration phase can obscure which agent is causing nausea, vomiting, or appetite changes, making it harder to adjust safely

For in vivo experiment, FOXO4DRI was dissolved in sterile PBS to generate a 5 mg/ml stock solution