To improve outcomes, combination therapies including Amphotericin B, Miltefosine, and Paromomycin are being evaluated, with trials like NCT01122771 exploring shorter regimens to increase treatment adherence and reduce toxicity (Rahman et al., 2017)
Benzyl alcohol toxicity in neonates was documented in published case series and FDA communications beginning in the early 1980s, describing a syndrome characterised by metabolic acidosis, gasping respirations, CNS depression, and in some cases death now referred to as 'gasping syndrome.' Neonates lack the hepatic enzyme capacity to metabolise benzyl alcohol effectively, leading to toxic accumulation of benzoic acid
Multiple-dose pharmacokinetics and bioequivalence of L-carnitine 330-mg tablet versus 1-g chewable tablet versus enteral solution in healthy adult male volunteers
Most peptide therapies are injected into the fatty tissue just beneath the skin using a subcutaneous injection
In individuals with nutritional deficiencies (e.g., strict vegetarians without supplements), injections may be given less frequently or replaced by oral supplements once levels stabilize
Effect of physical activity on sex hormones in women: A systematic review and meta-analysis of randomized controlled trials
