Fitten LJ, Ortiz F, Ponton M
It confirmed ferroptosis as the core mechanism in PD pathogenesis synergistically induced by iron overload and inflammation, which activate ferroptosis by disrupting iron metabolism, inhibiting the antioxidant system and exacerbating lipid peroxidation, further causing dopaminergic neuronal damage, -syn aggregation, and PD-characteristic motor/cognitive impairments (186).Treating SH-SY5Y dopamine neurons with rotenone and using RhoNox-1 staining, followed by confocal microscopy observation and flow cytometry analysis, revealed significantly higher intracellular Fe 2+ in the rotenone group, confirming cellular iron overload (187)
Xiang M, Wu X, Jing H, Novakovic VA, Shi J (2023) The intersection of obesity and (long) COVID-19: hypoxia, thrombotic inflammation, and vascular endothelial injury
Advice for pharmacists The pharmacist has a central role in supporting patients on AOM
The rising demand from emerging markets, especially in Asia-Pacific, presents significant regional expansion opportunities
Primary endpoint The primary endpoints are alteration of transcriptomic profile of human tongue tissue as changes in expression level from baseline to follow up after 16 weeks of treatment, measured by RNA sequencing, and change in taste sensitivity as detected by chemical gustometry