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The initial insult of Pol- inhibition by NRTIs not only depletes mtDNA but can also introduce replication errors, leading to point mutations and large-scale deletions such as the 4977-bp common deletion (111)

Available evidence, primarily from case reports and post-marketing surveillance, suggests that gastrointestinal symptoms related to GLP-1 receptor agonists are typically reversible upon discontinuation of the medication, though the timeframe and extent of recovery can vary considerably between individuals

Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, et al