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[0025] His racemization impurities are reduced by using the coupling system of Boc-His(Trt)-OH and Boc-His(Boc)-OH.DCHA in the present invention

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The so-called obesity epidemic harms people living in larger bodies, contributes to anti-fatness and body weight bias, and can lead to mental health problems and eating disorders, such as binge eating disorder, anorexia nervosa, or bulimia nervosa

Nausea, vomiting, diarrhoea, constipation, reflux, or low appetite should be monitored, especially during dose changes

While prevalence is highest in high-income countries, a large share of the increase (around 55%) has occurred in rural areas in LMICs across South-East Asia, Latin America, Central Asia, and North Africa (58) and by 2035 over 4 billion people worldwide will be living with excess weight or obesity53% more than in 2020 ( Figure 1 )