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Furthermore, GLP-1 and glucose-dependent insulinotropic polypeptides have been shown to induce substance P release from sensory nerves expressing TRPV1 and TRPA1, broadening the potential pain modulation mechanisms of GLP-1 and suggesting their application in peripheral pain management 64

The new pill form changes how GLP-1s are taken but not the underlying reality that outcomes hinge on day-to-day behavior change

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Keep in mind this was a small study conducted entirely in women using a different saffron extract than the one in Lemme Reset, so its hard to know how directly the findings applyor how meaningful the snacking reduction is for weight loss in the broader population

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Others may need several months before their readings change