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Zepbound activates both GIP and GLP-1 receptors, meaning it has a dual mechanism of action, compared to semaglutide and orforglipron, which only activate GLP-1 receptors

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Rimonabant, the first selective central cannabinoid (CB1) receptor antagonist, was not approved by the FDA because of concerns regarding psychiatric adverse events including depression, anxiety and suicidal ideation [20]

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Highly effective medications such as GLP-1 receptor agonists have transformed clinical outcomes, producing substantial and sustained weight reduction while improving metabolic health

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