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Therefore, targeting GPX4 transcription and neutrophil ferroptosis may have therapeutic benefits for SLE patients

Wang C, Ahlford A, Jarvinen TM, Nordmark G, Eloranta ML, Gunnarsson I et al (2013) Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

481 This suggests that ACSL4 initiates a cascade that links ferroptosis to pyroptosis, thereby promoting cardiac hypertrophy and responding to the hemodynamic stress induced by aortic constriction

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